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PPM1D FISH Probe

The PPM1D FISH probe is designed to hybridize to the PPM1D gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
PPM1D-20-OR  (Standard Design) 20 (40 μL) 200 μL
PPM1D-20-RE 20 (40 μL) 200 μL
PPM1D-20-GO 20 (40 μL) 200 μL
PPM1D-20-GR 20 (40 μL) 200 μL
PPM1D-20-AQ 20 (40 μL) 200 μL
PPM1D-20-DIG 20 (40 μL) 200 μL
PPM1D-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PPM1D

Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1D

Chromosome: CHR17: 58677543-58743640

Locus: 17q23.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: PPM1D FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PPM1D-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping