POMC Break Apart FISH Probe
Empire Genomics’ POMC Break Apart FISH Probe is designed to flank the POMC gene and is typically used for detecting POMC rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POMCBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| POMCBA-20-AQOR | 20 (40 μL) | 200 μL |
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| POMCBA-20-GOGR | 20 (40 μL) | 200 μL |
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| POMCBA-20-GORE | 20 (40 μL) | 200 μL |
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| POMCBA-20-GRGO | 20 (40 μL) | 200 μL |
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| POMCBA-20-GRRE | 20 (40 μL) | 200 μL |
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| POMCBA-20-ORGR | 20 (40 μL) | 200 μL |
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| POMCBA-20-REGO | 20 (40 μL) | 200 μL |
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| POMCBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: POMC
Gene Name: Proopiomelanocortin
Chromosome: CHR2: 25383721-25391559
Locus: 2p23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: POMC FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: POMC-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping