PML Break Apart FISH Probe
Empire Genomics’ PML Break Apart FISH Probe is designed to flank the PML gene and is typically used for detecting PML rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PMLBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PMLBA-20-AQOR | 20 (40 μL) | 200 μL |
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| PMLBA-20-GOGR | 20 (40 μL) | 200 μL |
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| PMLBA-20-GORE | 20 (40 μL) | 200 μL |
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| PMLBA-20-GRGO | 20 (40 μL) | 200 μL |
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| PMLBA-20-GROR | 20 (40 μL) | 200 μL |
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| PMLBA-20-GRRE | 20 (40 μL) | 200 μL |
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| PMLBA-20-REGO | 20 (40 μL) | 200 μL |
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| PMLBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PML
Gene Name: Promyelocytic Leukemia
Chromosome: CHR15: 74287013-74340155
Locus: 15q24.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PML FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PML-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping