PMEL FISH Probe
The PMEL FISH probe is designed to hybridize to the PMEL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PMEL-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PMEL-20-RE | 20 (40 μL) | 200 μL |  |
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| PMEL-20-GO | 20 (40 μL) | 200 μL |  |
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| PMEL-20-GR | 20 (40 μL) | 200 μL |  |
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| PMEL-20-AQ | 20 (40 μL) | 200 μL |  |
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| PMEL-20-DIG | 20 (40 μL) | 200 μL |  |
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| PMEL-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Gene Details
Gene Symbol: PMEL
Gene Name: Premelanosome Protein
Chromosome: CHR12: 56347888-56360496
Locus: 12q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PMEL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PMEL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping