PLN FISH Probe
The PLN FISH probe is designed to hybridize to the PLN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PLN-20-RE | 20 (40 μL) | 200 μL |  |
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| PLN-20-GO | 20 (40 μL) | 200 μL |  |
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| PLN-20-GR | 20 (40 μL) | 200 μL |  |
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| PLN-20-AQ | 20 (40 μL) | 200 μL |  |
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| PLN-20-DIG | 20 (40 μL) | 200 μL |  |
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| PLN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: PLN
Gene Name: Phospholamban
Chromosome: CHR6: 118869441-118881587
Locus: 6q22.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PLN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PLN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping