PLEKHM2 FISH Probe
The PLEKHM2 FISH probe is designed to hybridize to the PLEKHM2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLEKHM2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PLEKHM2-20-RE | 20 (40 μL) | 200 μL |  |
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| PLEKHM2-20-GO | 20 (40 μL) | 200 μL |  |
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| PLEKHM2-20-GR | 20 (40 μL) | 200 μL |  |
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| PLEKHM2-20-AQ | 20 (40 μL) | 200 μL |  |
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| PLEKHM2-20-DIG | 20 (40 μL) | 200 μL |  |
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| PLEKHM2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Gene Details
Gene Symbol: PLEKHM2
Gene Name: Pleckstrin Homology And RUN Domain Containing M2
Chromosome: CHR1: 16010826-16061264
Locus: 1p36.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PLEKHM2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PLEKHM2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping