The PLEKHM2 FISH probe is designed to hybridize to the PLEKHM2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PLEKHM2-20-OR  (Standard Design) 20 (40 μL) 200 μL
PLEKHM2-20-RE 20 (40 μL) 200 μL
PLEKHM2-20-GO 20 (40 μL) 200 μL
PLEKHM2-20-GR 20 (40 μL) 200 μL
PLEKHM2-20-AQ 20 (40 μL) 200 μL
PLEKHM2-20-DIG 20 (40 μL) 200 μL
PLEKHM2-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]

Gene Details

Gene Symbol: PLEKHM2

Gene Name: Pleckstrin Homology And RUN Domain Containing M2

Chromosome: CHR1: 16010826-16061264

Locus: 1p36.21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: PLEKHM2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL


Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping