PKD1 FISH Probe
The PKD1 FISH probe is designed to hybridize to the PKD1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PKD1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PKD1-20-RE | 20 (40 μL) | 200 μL |  |
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| PKD1-20-GO | 20 (40 μL) | 200 μL |  |
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| PKD1-20-GR | 20 (40 μL) | 200 μL |  |
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| PKD1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PKD1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PKD1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]
Gene Details
Gene Symbol: PKD1
Gene Name: Polycystin 1, Transient Receptor Potential Channel Interacting
Chromosome: CHR16: 2138710-2185899
Locus: 16p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PKD1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PKD1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping