PIKFYVE FISH Probe
The PIKFYVE FISH probe is designed to hybridize to the PIKFYVE gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PIKFYVE-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PIKFYVE-20-RE | 20 (40 μL) | 200 μL |  |
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| PIKFYVE-20-GO | 20 (40 μL) | 200 μL |  |
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| PIKFYVE-20-GR | 20 (40 μL) | 200 μL |  |
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| PIKFYVE-20-AQ | 20 (40 μL) | 200 μL |  |
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| PIKFYVE-20-DIG | 20 (40 μL) | 200 μL |  |
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| PIKFYVE-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Gene Details
Gene Symbol: PIKFYVE
Gene Name: Phosphoinositide Kinase, FYVE-type Zinc Finger Containing
Chromosome: CHR2: 209130990-209223475
Locus: 2q34
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PIKFYVE FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PIKFYVE-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping