PFKFB4 Break Apart FISH Probe
Empire Genomics’ PFKFB4 Break Apart FISH Probe is designed to flank the PFKFB4 gene and is typically used for detecting PFKFB4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFKFB4BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-GORE | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-ORGR | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-REGO | 20 (40 μL) | 200 μL |
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| PFKFB4BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Details
Gene Symbol: PFKFB4
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Chromosome: CHR3: 48555116-48594227
Locus: 3p21.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PFKFB4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PFKFB4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping