PFKFB3 Break Apart FISH Probe
Empire Genomics’ PFKFB3 Break Apart FISH Probe is designed to flank the PFKFB3 gene and is typically used for detecting PFKFB3 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFKFB3BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-GORE | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-GROR | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-REGO | 20 (40 μL) | 200 μL |
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| PFKFB3BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: PFKFB3
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Chromosome: CHR10: 6186842-6277507
Locus: 10p15.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PFKFB3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PFKFB3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping