PFKFB3 FISH Probe
The PFKFB3 FISH probe is designed to hybridize to the PFKFB3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PFKFB3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PFKFB3-20-RE | 20 (40 μL) | 200 μL |  |
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| PFKFB3-20-GO | 20 (40 μL) | 200 μL |  |
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| PFKFB3-20-GR | 20 (40 μL) | 200 μL |  |
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| PFKFB3-20-AQ | 20 (40 μL) | 200 μL |  |
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| PFKFB3-20-DIG | 20 (40 μL) | 200 μL |  |
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| PFKFB3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: PFKFB3
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Chromosome: CHR10: 6186842-6277507
Locus: 10p15.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PFKFB3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PFKFB3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping