PDZD3 FISH Probe
The PDZD3 FISH probe is designed to hybridize to the PDZD3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDZD3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-RE | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-GO | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-GR | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-AQ | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-DIG | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
Gene Details
Gene Symbol: PDZD3
Gene Name: PDZ Domain Containing 3
Chromosome: CHR11: 119056165-119060932
Locus: 11q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PDZD3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PDZD3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping