PDP1 FISH Probe
The PDP1 FISH probe is designed to hybridize to the PDP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PDP1-20-RE | 20 (40 μL) | 200 μL |  |
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| PDP1-20-GO | 20 (40 μL) | 200 μL |  |
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| PDP1-20-GR | 20 (40 μL) | 200 μL |  |
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| PDP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PDP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PDP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Gene Details
Gene Symbol: PDP1
Gene Name: Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1
Chromosome: CHR8: 94929082-94938296
Locus: 8q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PDP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PDP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping