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PDHX Break Apart FISH Probe

Empire Genomics’ PDHX Break Apart FISH Probe is designed to flank the PDHX gene and is typically used for detecting PDHX rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PDHXBA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PDHXBA-20-AQOR 20 (40 μL) 200 μL
PDHXBA-20-GOGR 20 (40 μL) 200 μL
PDHXBA-20-GORE 20 (40 μL) 200 μL
PDHXBA-20-GRGO 20 (40 μL) 200 μL
PDHXBA-20-GROR 20 (40 μL) 200 μL
PDHXBA-20-GRRE 20 (40 μL) 200 μL
PDHXBA-20-REGO 20 (40 μL) 200 μL
PDHXBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Gene Details

Gene Symbol: PDHX

Gene Name: Pyruvate Dehydrogenase Complex Component X

Chromosome: CHR11: 34937676-35017675

Locus: 11p13

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: PDHX FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PDHX-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping