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PDCD1 Break Apart FISH Probe

Empire Genomics’ PDCD1 Break Apart FISH Probe is designed to flank the PDCD1 gene and is typically used for detecting PDCD1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
PDCD1BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
PDCD1BA-20-AQOR 20 (40 μL) 200 μL
PDCD1BA-20-GOGR 20 (40 μL) 200 μL
PDCD1BA-20-GORE 20 (40 μL) 200 μL
PDCD1BA-20-GRGO 20 (40 μL) 200 μL
PDCD1BA-20-GRRE 20 (40 μL) 200 μL
PDCD1BA-20-ORGR 20 (40 μL) 200 μL
PDCD1BA-20-REGO 20 (40 μL) 200 μL
PDCD1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PDCD1

Gene Name: Programmed Cell Death 1

Chromosome: CHR2: 242792032-242801058

Locus: 2q37.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

High-throughput Sequencing of Subcutaneous Panniculitis-like T-Cell Lymphoma Reveals Candidate Pathogenic Mutations

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cancer that’s challenging to distinguish from lupus panniculitis (LP). Few studies have been conducted on the genetic and molecular development of the disease. This team performed whole-exome sequencing on 4 SPTCLs and 1 systemic T-cell lymphoma, along with 2 cases of LP. They also used targeted sequencing to analyze 41 genes (with known implications across hematolyhpoid malignancies) on 5 additional SPTCL biopsies. Empire Genomics’ PDCD1 and PIK3CD FISH probes were used to detect copy number variants in the 2 genes, which are abnormalities associated with lymphoma but not LP.
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Product Details

Product: PDCD1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PDCD1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping