PCSK2 Break Apart FISH Probe
Empire Genomics’ PCSK2 Break Apart FISH Probe is designed to flank the PCSK2 gene and is typically used for detecting PCSK2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCSK2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-GORE | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-GROR | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-REGO | 20 (40 μL) | 200 μL |
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| PCSK2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Gene Details
Gene Symbol: PCSK2
Gene Name: Proprotein Convertase Subtilisin/kexin Type 2
Chromosome: CHR20: 17206751-17465222
Locus: 20p12.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PCSK2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PCSK2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping