PCSK2 FISH Probe
The PCSK2 FISH probe is designed to hybridize to the PCSK2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PCSK2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| PCSK2-20-RE | 20 (40 μL) | 200 μL |  |
|
| PCSK2-20-GO | 20 (40 μL) | 200 μL |  |
|
| PCSK2-20-GR | 20 (40 μL) | 200 μL |  |
|
| PCSK2-20-AQ | 20 (40 μL) | 200 μL |  |
|
| PCSK2-20-DIG | 20 (40 μL) | 200 μL |  |
|
| PCSK2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Gene Details
Gene Symbol: PCSK2
Gene Name: Proprotein Convertase Subtilisin/kexin Type 2
Chromosome: CHR20: 17206751-17465222
Locus: 20p12.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: PCSK2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PCSK2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping