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PCGF2 Break Apart FISH Probe

Empire Genomics’ PCGF2 Break Apart FISH Probe is designed to flank the PCGF2 gene and is typically used for detecting PCGF2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
PCGF2BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
PCGF2BA-20-AQOR 20 (40 μL) 200 μL
PCGF2BA-20-GOGR 20 (40 μL) 200 μL
PCGF2BA-20-GORE 20 (40 μL) 200 μL
PCGF2BA-20-GRGO 20 (40 μL) 200 μL
PCGF2BA-20-GRRE 20 (40 μL) 200 μL
PCGF2BA-20-ORGR 20 (40 μL) 200 μL
PCGF2BA-20-REGO 20 (40 μL) 200 μL
PCGF2BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PCGF2

Gene Name: Polycomb Group Ring Finger 2

Chromosome: CHR17: 36890149-36904558

Locus: 17q12

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Role of MEL-18 Amplification in Anti-HER2 Therapy of Breast Cancer

HER2 is a receptor that can trigger oncogenic signals, which can be amplified in breast cancer. Under study was the connection between amplification of the MEL-18 gene and HER2-positive breast cancer. FISH analysis was used to verify the amplification of MEL-18. Our PCGF2 FISH probe was used to monitor the number of gene copies. It was determined that amplification of MEL-18 is a unique biomarker for HER2-positive breast cancer.
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Product Details

Product: PCGF2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PCGF2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping