PCDH-GAMMA-B4 FISH Probe
The PCDH-GAMMA-B4 FISH probe is designed to hybridize to the PCDH-GAMMA-B4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PCDHGB4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PCDHGB4-20-RE | 20 (40 μL) | 200 μL |  |
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| PCDHGB4-20-GO | 20 (40 μL) | 200 μL |  |
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| PCDHGB4-20-GR | 20 (40 μL) | 200 μL |  |
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| PCDHGB4-20-AQ | 20 (40 μL) | 200 μL |  |
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| PCDHGB4-20-DIG | 20 (40 μL) | 200 μL |  |
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| PCDHGB4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PCDHGB4
Gene Name: Protocadherin Gamma Subfamily B, 4
Chromosome: CHR5: 140767451-140892546
Locus: 5q31.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PCDH-GAMMA-B4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PCDHGB4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping