PCBP2 FISH Probe
The PCBP2 FISH probe is designed to hybridize to the PCBP2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PCBP2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PCBP2-20-RE | 20 (40 μL) | 200 μL |  |
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| PCBP2-20-GO | 20 (40 μL) | 200 μL |  |
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| PCBP2-20-GR | 20 (40 μL) | 200 μL |  |
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| PCBP2-20-AQ | 20 (40 μL) | 200 μL |  |
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| PCBP2-20-DIG | 20 (40 μL) | 200 μL |  |
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| PCBP2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Gene Details
Gene Symbol: PCBP2
Gene Name: Poly(rC) Binding Protein 2
Chromosome: CHR12: 53845885-53874946
Locus: 12q13.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PCBP2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PCBP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping