PC FISH Probe
The PC FISH probe is designed to hybridize to the PC gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PC-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PC-20-RE | 20 (40 μL) | 200 μL |  |
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| PC-20-GO | 20 (40 μL) | 200 μL |  |
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| PC-20-GR | 20 (40 μL) | 200 μL |  |
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| PC-20-AQ | 20 (40 μL) | 200 μL |  |
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| PC-20-DIG | 20 (40 μL) | 200 μL |  |
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| PC-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PC
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996-66725847
Locus: 11q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PC FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PC-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping