PAX5 FISH Probe
The PAX5 FISH probe is designed to hybridize to the PAX5 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAX5-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PAX5-20-RE | 20 (40 μL) | 200 μL |  |
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| PAX5-20-GO | 20 (40 μL) | 200 μL |  |
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| PAX5-20-GR | 20 (40 μL) | 200 μL |  |
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| PAX5-20-AQ | 20 (40 μL) | 200 μL |  |
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| PAX5-20-DIG | 20 (40 μL) | 200 μL |  |
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| PAX5-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: PAX5
Gene Name: Paired Box 5
Chromosome: CHR9: 36838530-37034476
Locus: 9p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Diffuse large B-cell lymphoma carrying t(9;14)(p13;q32)/PAX5-immunoglobulin heavy chain gene is characterized by nuclear positivity of MUM1 and PAX5 by immunohistochemistry
Product Details
Product: PAX5 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PAX5-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping