PATZ1 FISH Probe
The PATZ1 FISH probe is designed to hybridize to the PATZ1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PATZ1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PATZ1-20-RE | 20 (40 μL) | 200 μL |  |
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| PATZ1-20-GO | 20 (40 μL) | 200 μL |  |
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| PATZ1-20-GR | 20 (40 μL) | 200 μL |  |
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| PATZ1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PATZ1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PATZ1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PATZ1
Gene Name: POZ/BTB And AT Hook Containing Zinc Finger 1
Chromosome: CHR22: 31721789-31742249
Locus: 22q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PATZ1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PATZ1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping