PAPPA FISH Probe
The PAPPA FISH probe is designed to hybridize to the PAPPA gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAPPA-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-RE | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-GO | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-GR | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-AQ | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-DIG | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: PAPPA
Gene Name: Pappalysin 1
Chromosome: CHR9: 118916070-119164600
Locus: 9q33.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PAPPA FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PAPPA-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping