PABPC4 FISH Probe
The PABPC4 FISH probe is designed to hybridize to the PABPC4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PABPC4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PABPC4-20-RE | 20 (40 μL) | 200 μL |  |
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| PABPC4-20-GO | 20 (40 μL) | 200 μL |  |
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| PABPC4-20-GR | 20 (40 μL) | 200 μL |  |
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| PABPC4-20-AQ | 20 (40 μL) | 200 μL |  |
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| PABPC4-20-DIG | 20 (40 μL) | 200 μL |  |
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| PABPC4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Details
Gene Symbol: PABPC4
Gene Name: Poly(A) Binding Protein Cytoplasmic 4
Chromosome: CHR1: 40026484-40042521
Locus: 1p34.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PABPC4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PABPC4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping