NUB1 FISH Probe
The NUB1 FISH probe is designed to hybridize to the NUB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NUB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| NUB1-20-RE | 20 (40 μL) | 200 μL |  |
|
| NUB1-20-GO | 20 (40 μL) | 200 μL |  |
|
| NUB1-20-GR | 20 (40 μL) | 200 μL |  |
|
| NUB1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| NUB1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| NUB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: NUB1
Gene Name: Negative Regulator Of Ubiquitin Like Proteins 1
Chromosome: CHR7: 151038846-151075548
Locus: 7q36.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: NUB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NUB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping