NRG3 FISH Probe
The NRG3 FISH probe is designed to hybridize to the NRG3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NRG3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NRG3-20-RE | 20 (40 μL) | 200 μL |  |
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| NRG3-20-GO | 20 (40 μL) | 200 μL |  |
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| NRG3-20-GR | 20 (40 μL) | 200 μL |  |
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| NRG3-20-AQ | 20 (40 μL) | 200 μL |  |
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| NRG3-20-DIG | 20 (40 μL) | 200 μL |  |
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| NRG3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Gene Details
Gene Symbol: NRG3
Gene Name: Neuregulin 3
Chromosome: CHR10: 83635069-84746935
Locus: 10q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NRG3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NRG3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping