NPR1 FISH Probe
The NPR1 FISH probe is designed to hybridize to the NPR1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NPR1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NPR1-20-RE | 20 (40 μL) | 200 μL |  |
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| NPR1-20-GO | 20 (40 μL) | 200 μL |  |
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| NPR1-20-GR | 20 (40 μL) | 200 μL |  |
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| NPR1-20-AQ | 20 (40 μL) | 200 μL |  |
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| NPR1-20-DIG | 20 (40 μL) | 200 μL |  |
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| NPR1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Gene Details
Gene Symbol: NPR1
Gene Name: Natriuretic Peptide Receptor 1
Chromosome: CHR1: 153651163-153666468
Locus: 1q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NPR1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NPR1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping