NPC1L1 Break Apart FISH Probe
Empire Genomics’ NPC1L1 Break Apart FISH Probe is designed to flank the NPC1L1 gene and is typically used for detecting NPC1L1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NPC1L1BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-GORE | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-REGO | 20 (40 μL) | 200 μL |
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| NPC1L1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Details
Gene Symbol: NPC1L1
Gene Name: NPC1 Like Intracellular Cholesterol Transporter 1
Chromosome: CHR7: 44552134-44580914
Locus: 7p13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NPC1L1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NPC1L1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping