NOG FISH Probe
The NOG FISH probe is designed to hybridize to the NOG gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NOG-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NOG-20-RE | 20 (40 μL) | 200 μL |  |
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| NOG-20-GO | 20 (40 μL) | 200 μL |  |
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| NOG-20-GR | 20 (40 μL) | 200 μL |  |
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| NOG-20-AQ | 20 (40 μL) | 200 μL |  |
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| NOG-20-DIG | 20 (40 μL) | 200 μL |  |
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| NOG-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: NOG
Gene Name: Noggin
Chromosome: CHR17: 54671059-54672951
Locus: 17q22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NOG FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NOG-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping