NLRP3 FISH Probe
The NLRP3 FISH probe is designed to hybridize to the NLRP3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NLRP3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NLRP3-20-RE | 20 (40 μL) | 200 μL |  |
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| NLRP3-20-GO | 20 (40 μL) | 200 μL |  |
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| NLRP3-20-GR | 20 (40 μL) | 200 μL |  |
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| NLRP3-20-AQ | 20 (40 μL) | 200 μL |  |
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| NLRP3-20-DIG | 20 (40 μL) | 200 μL |  |
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| NLRP3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
Gene Details
Gene Symbol: NLRP3
Gene Name: NLR Family Pyrin Domain Containing 3
Chromosome: CHR1: 247579457-247612406
Locus: 1q44
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NLRP3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NLRP3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping