NIPBL FISH Probe
The NIPBL FISH probe is designed to hybridize to the NIPBL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NIPBL-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NIPBL-20-RE | 20 (40 μL) | 200 μL |  |
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| NIPBL-20-GO | 20 (40 μL) | 200 μL |  |
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| NIPBL-20-GR | 20 (40 μL) | 200 μL |  |
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| NIPBL-20-AQ | 20 (40 μL) | 200 μL |  |
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| NIPBL-20-DIG | 20 (40 μL) | 200 μL |  |
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| NIPBL-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: NIPBL
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860-37065921
Locus: 5p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NIPBL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NIPBL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping