N2 FISH Probe
The N2 FISH probe is designed to hybridize to the N2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NOTCH2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| NOTCH2-20-RE | 20 (40 μL) | 200 μL |  |
|
| NOTCH2-20-GO | 20 (40 μL) | 200 μL |  |
|
| NOTCH2-20-GR | 20 (40 μL) | 200 μL |  |
|
| NOTCH2-20-AQ | 20 (40 μL) | 200 μL |  |
|
| NOTCH2-20-DIG | 20 (40 μL) | 200 μL |  |
|
| NOTCH2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Details
Gene Symbol: NOTCH2
Gene Name: Notch 2
Chromosome: CHR1: 120454175-120612317
Locus: 1p12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: N2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NOTCH2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping