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MYL FISH Probe

The MYL FISH probe is designed to hybridize to the MYL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PML-20-OR  (Standard Design) 20 (40 μL) 200 μL
PML-20-RE 20 (40 μL) 200 μL
PML-20-GO 20 (40 μL) 200 μL
PML-20-GR 20 (40 μL) 200 μL
PML-20-AQ 20 (40 μL) 200 μL
PML-20-DIG 20 (40 μL) 200 μL
PML-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PML

Gene Name: Promyelocytic Leukemia

Chromosome: CHR15: 74287013-74340155

Locus: 15q24.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: MYL FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PML-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping