MYH11 Break Apart FISH Probe
Empire Genomics’ MYH11 Break Apart FISH Probe is designed to flank the MYH11 gene and is typically used for detecting MYH11 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYH11BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MYH11BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MYH11
Gene Name: Myosin Heavy Chain 11
Chromosome: CHR16: 15796991-15950887
Locus: 16p13.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: MYH11 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MYH11-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping