MVCD1 FISH Probe
The MVCD1 FISH probe is designed to hybridize to the MVCD1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| VEGFA-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| VEGFA-20-RE | 20 (40 μL) | 200 μL |  |
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| VEGFA-20-GO | 20 (40 μL) | 200 μL |  |
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| VEGFA-20-GR | 20 (40 μL) | 200 μL |  |
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| VEGFA-20-AQ | 20 (40 μL) | 200 μL |  |
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| VEGFA-20-DIG | 20 (40 μL) | 200 μL |  |
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| VEGFA-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Gene Details
Gene Symbol: VEGFA
Gene Name: Vascular Endothelial Growth Factor A
Chromosome: CHR6: 43737945-43754223
Locus: 6p21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MVCD1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: VEGFA-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping