MRVI1 FISH Probe
The MRVI1 FISH probe is designed to hybridize to the MRVI1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MRVI1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MRVI1-20-RE | 20 (40 μL) | 200 μL |  |
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| MRVI1-20-GO | 20 (40 μL) | 200 μL |  |
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| MRVI1-20-GR | 20 (40 μL) | 200 μL |  |
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| MRVI1-20-AQ | 20 (40 μL) | 200 μL |  |
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| MRVI1-20-DIG | 20 (40 μL) | 200 μL |  |
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| MRVI1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
Gene Details
Gene Symbol: MRVI1
Gene Name: Murine Retrovirus Integration Site 1 Homolog
Chromosome: CHR11: 10594637-10715535
Locus: 11p15.4
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MRVI1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MRVI1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping