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MRPS23 Break Apart FISH Probe

Empire Genomics’ MRPS23 Break Apart FISH Probe is designed to flank the MRPS23 gene and is typically used for detecting MRPS23 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
MRPS23BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
MRPS23BA-20-AQOR 20 (40 μL) 200 μL
MRPS23BA-20-GOGR 20 (40 μL) 200 μL
MRPS23BA-20-GORE 20 (40 μL) 200 μL
MRPS23BA-20-GRGO 20 (40 μL) 200 μL
MRPS23BA-20-GRRE 20 (40 μL) 200 μL
MRPS23BA-20-ORGR 20 (40 μL) 200 μL
MRPS23BA-20-REGO 20 (40 μL) 200 μL
MRPS23BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: MRPS23

Gene Name: Mitochondrial Ribosomal Protein S23

Chromosome: CHR17: 55916286-55927433

Locus: 17q22

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes

MRPS23 overexpression is linked to increased tumor cell proliferation in breast cancer. This study investigated the association between MRPS23 gene amplification and molecular subtype, tumor proliferation, and prognosis in breast cancer from two cohorts: one from the Cancer Registry of Norway, and one from the METABRIC database. Our MRPS23 FISH probe was used to detect MRPS23 amplification in the Norway cohort, which consisted of 144 BC cases. MRPS23 amplification was more prevalent in non-basal subtypes, and, as expected, correlated with tumor proliferation, but no association was found between MRPS23 amplification and prognosis.
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Product Details

Product: MRPS23 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: MRPS23-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping