MPTP-PEST FISH Probe
The MPTP-PEST FISH probe is designed to hybridize to the MPTP-PEST gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTPN12-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PTPN12-20-RE | 20 (40 μL) | 200 μL |  |
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| PTPN12-20-GO | 20 (40 μL) | 200 μL |  |
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| PTPN12-20-GR | 20 (40 μL) | 200 μL |  |
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| PTPN12-20-AQ | 20 (40 μL) | 200 μL |  |
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| PTPN12-20-DIG | 20 (40 μL) | 200 μL |  |
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| PTPN12-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Details
Gene Symbol: PTPN12
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 12
Chromosome: CHR7: 77166772-77269388
Locus: 7q11.23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MPTP-PEST FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTPN12-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping