MPL FISH Probe
The MPL FISH probe is designed to hybridize to the MPL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MPL-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MPL-20-RE | 20 (40 μL) | 200 μL |  |
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| MPL-20-GO | 20 (40 μL) | 200 μL |  |
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| MPL-20-GR | 20 (40 μL) | 200 μL |  |
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| MPL-20-AQ | 20 (40 μL) | 200 μL |  |
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| MPL-20-DIG | 20 (40 μL) | 200 μL |  |
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| MPL-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MPL
Gene Name: MPL Proto-oncogene, Thrombopoietin Receptor
Chromosome: CHR1: 43803474-43820135
Locus: 1p34.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MPL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MPL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping