MMP2 Break Apart FISH Probe
Empire Genomics’ MMP2 Break Apart FISH Probe is designed to flank the MMP2 gene and is typically used for detecting MMP2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MMP2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MMP2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| MMP2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| MMP2BA-20-GORE | 20 (40 μL) | 200 μL |
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| MMP2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| MMP2BA-20-GROR | 20 (40 μL) | 200 μL |
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| MMP2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| MMP2BA-20-REGO | 20 (40 μL) | 200 μL |
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| MMP2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Gene Details
Gene Symbol: MMP2
Gene Name: Matrix Metallopeptidase 2
Chromosome: CHR16: 55513080-55540586
Locus: 16q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MMP2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MMP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping