MKNK2 FISH Probe
The MKNK2 FISH probe is designed to hybridize to the MKNK2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MKNK2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MKNK2-20-RE | 20 (40 μL) | 200 μL |  |
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| MKNK2-20-GO | 20 (40 μL) | 200 μL |  |
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| MKNK2-20-GR | 20 (40 μL) | 200 μL |  |
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| MKNK2-20-AQ | 20 (40 μL) | 200 μL |  |
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| MKNK2-20-DIG | 20 (40 μL) | 200 μL |  |
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| MKNK2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: MKNK2
Gene Name: MAP Kinase Interacting Serine/threonine Kinase 2
Chromosome: CHR19: 2037469-2051243
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MKNK2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MKNK2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping