MGMT FISH Probe
The MGMT FISH probe is designed to hybridize to the MGMT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MGMT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MGMT-20-RE | 20 (40 μL) | 200 μL |  |
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| MGMT-20-GO | 20 (40 μL) | 200 μL |  |
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| MGMT-20-GR | 20 (40 μL) | 200 μL |  |
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| MGMT-20-AQ | 20 (40 μL) | 200 μL |  |
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| MGMT-20-DIG | 20 (40 μL) | 200 μL |  |
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| MGMT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Gene Details
Gene Symbol: MGMT
Gene Name: O-6-methylguanine-DNA Methyltransferase
Chromosome: CHR10: 131265453-131565783
Locus: 10q26.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: MGMT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MGMT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping