MEL1 FISH Probe
The MEL1 FISH probe is designed to hybridize to the MEL1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRDM16-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PRDM16-20-RE | 20 (40 μL) | 200 μL |  |
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| PRDM16-20-GO | 20 (40 μL) | 200 μL |  |
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| PRDM16-20-GR | 20 (40 μL) | 200 μL |  |
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| PRDM16-20-AQ | 20 (40 μL) | 200 μL |  |
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| PRDM16-20-DIG | 20 (40 μL) | 200 μL |  |
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| PRDM16-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PRDM16
Gene Name: PR/SET Domain 16
Chromosome: CHR1: 2985741-3355185
Locus: 1p36.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MEL1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRDM16-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping