MED12 FISH Probe
The MED12 FISH probe is designed to hybridize to the MED12 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MED12-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MED12-20-RE | 20 (40 μL) | 200 μL |  |
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| MED12-20-GO | 20 (40 μL) | 200 μL |  |
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| MED12-20-GR | 20 (40 μL) | 200 μL |  |
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| MED12-20-AQ | 20 (40 μL) | 200 μL |  |
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| MED12-20-DIG | 20 (40 μL) | 200 μL |  |
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| MED12-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
Gene Details
Gene Symbol: MED12
Gene Name: Mediator Complex Subunit 12
Chromosome: CHRX: 70338405-70362304
Locus: Xq13.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MED12 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MED12-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping