MCM6 Break Apart FISH Probe
Empire Genomics’ MCM6 Break Apart FISH Probe is designed to flank the MCM6 gene and is typically used for detecting MCM6 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MCM6BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MCM6BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
Gene Details
Gene Symbol: MCM6
Gene Name: Minichromosome Maintenance Complex Component 6
Chromosome: CHR2: 136597195-136634011
Locus: 2q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: MCM6 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MCM6-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping