MCM4 Break Apart FISH Probe
Empire Genomics’ MCM4 Break Apart FISH Probe is designed to flank the MCM4 gene and is typically used for detecting MCM4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCM4BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCM4BA-20-AQOR | 20 (40 μL) | 200 μL |
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| MCM4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| MCM4BA-20-GORE | 20 (40 μL) | 200 μL |
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| MCM4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| MCM4BA-20-GROR | 20 (40 μL) | 200 μL |
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| MCM4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| MCM4BA-20-REGO | 20 (40 μL) | 200 μL |
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| MCM4BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MCM4
Gene Name: Minichromosome Maintenance Complex Component 4
Chromosome: CHR8: 48872762-48890719
Locus: 8q11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MCM4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MCM4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping