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MCFD2 FISH Probe

The MCFD2 FISH probe is designed to hybridize to the MCFD2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
MCFD2-20-OR  (Standard Design) 20 (40 μL) 200 μL
MCFD2-20-RE 20 (40 μL) 200 μL
MCFD2-20-GO 20 (40 μL) 200 μL
MCFD2-20-GR 20 (40 μL) 200 μL
MCFD2-20-AQ 20 (40 μL) 200 μL
MCFD2-20-DIG 20 (40 μL) 200 μL
MCFD2-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2016]

Gene Details

Gene Symbol: MCFD2

Gene Name: Multiple Coagulation Factor Deficiency 2

Chromosome: CHR2: 47129008-47168994

Locus: 2p21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: MCFD2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: MCFD2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping