MBD5-1 FISH Probe
The MBD5-1 FISH probe is designed to hybridize to the MBD5-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MBD5-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MBD5-20-RE | 20 (40 μL) | 200 μL |  |
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| MBD5-20-GO | 20 (40 μL) | 200 μL |  |
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| MBD5-20-GR | 20 (40 μL) | 200 μL |  |
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| MBD5-20-AQ | 20 (40 μL) | 200 μL |  |
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| MBD5-20-DIG | 20 (40 μL) | 200 μL |  |
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| MBD5-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Jul 2017]
Gene Details
Gene Symbol: MBD5
Gene Name: Methyl-CpG Binding Domain Protein 5
Chromosome: CHR2: 148778579-149271044
Locus: 2q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MBD5-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MBD5-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping