MBD2 FISH Probe
The MBD2 FISH probe is designed to hybridize to the MBD2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MBD2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MBD2-20-RE | 20 (40 μL) | 200 μL |  |
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| MBD2-20-GO | 20 (40 μL) | 200 μL |  |
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| MBD2-20-GR | 20 (40 μL) | 200 μL |  |
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| MBD2-20-AQ | 20 (40 μL) | 200 μL |  |
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| MBD2-20-DIG | 20 (40 μL) | 200 μL |  |
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| MBD2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: MBD2
Gene Name: Methyl-CpG Binding Domain Protein 2
Chromosome: CHR18: 51677970-51751158
Locus: 18q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MBD2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MBD2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping